The Mamma Mia Study will address a gap in the literature by evaluating a universal preventive intervention for perinatal depressive symptoms— “Mamma Mia,” an internet- based individualized program— in a large scale randomized controlled study. With our Norwegian colleagues, we recently established the feasibility and efficacy of “Mamma Mia” for postpartum depressive symptoms in 1342 women in Norway. The proposed study builds upon these findings by adapting the intervention for a diverse U.S. audience and adding an element of guided support (“Mamma Mia Plus”) to enhance adherence. Hence, the primary aim of this three-arm randomized controlled trial is to test the effects of “Mamma Mia” versus “Mamma Mia Plus” versus the usual care on depressive symptoms for diverse perinatal women in the U.S. (n=1950). The secondary aim is to evaluate effects on subjective well-being, anxiety, and stress. The tertiary aim is to evaluate contextual variables (moderators) and potential mechanisms (mediators) of the effects, in order to prepare for future studies on implementation strategies. If proven efficacious, “Mamma Mia” may be a low-cost, sustainable, and translatable option for prevention of and intervention in perinatal depression.
This study is funded by the National Institutes of Health, Eunice Kennedy Shriver National Institute for Child Health and Human Development (R01HD100395; PI: Kinser)